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| Title: | Release and mobilization of haematopoietic cells |
| Inventors: | Comer, Michael Berisford; Oxford, United Kingdom McCourt, Matthew John; Oxford, United Kingdom Wood, Lars Michael; Oxford, United Kingdom Hunter, Michael George; Oxford, United Kingdom Edwards, Richard Mark; Oxford, United Kingdom |
| Summary: | Described herein are novel uses of stem cell inhibitors for promoting the release and mobilization of hematopoietic cells from mammalian marrow. The invention relates to stem cell inhibitors such as murine and human macrophage inflammatory protein-1alpha (muMIP-1alpha and huMIP-1alpha/LD78), and analogues and variants thereof, and methods of their use in the harvesting of hematopoietic cells prior to autologous or heterologous transportation. Therapeutic applications are included in the enhancement of responses against infection, and in the treatment and prevention of neutropenia. |
| Abstract: | Stem cell inhibitors such as murine and human macrophage inflammatory protein-1alpha (muMIP-1alpha and huMIP-1alpha/LD78) and their analogues and variants enhance the release and mobilization of haematopoietic cells. This property makes them useful in enhancing responses against infection and in cell harvesting. |
| US Patent Website: | Click Here for Full Text of Patent |
| Title Number: | US5925568 |
| Application Number: | US1996000545587 |
| Date Filed: | 16/01/1996 |
| Date Published: | 20/07/1999 |
| Assignee: | British Biotech Pharmaceuticals Limited, Oxford, United Kingdom |