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Stem Cell Related Patent Number US6812027
| Title: | Discovery, localization, harvest, and propagation of an FGF2 and BDNF-responsive population of neural and neuronal progenitor cells in the adult human forebrain | | Inventors: | Goldman, Steven A.; South Salem, NY, USA
Nedergaard, Maiken; South Salem, NY, USA | | Summary: | Described herein are human neural or neuronal progenitor cells isolated from non-embryonal human brain tissue and committed to the formation of neurons, wherein the neurons express a Hu protein. The invention relates to such cells which have been identified in histological sections of the adult human brain, and methods by which neuronal progenitor cells derived from human brain tissue are localized, characterized, harvested, and propagated. Additional methods are provided for the introduction and expression of genes in the brain. Therapeutic applications are included, such as the treatment of neurological diseases including Parkinson's disease, demyelinating diseases, ischemic conditions and traumatic brain injury. | | Abstract: | The present invention provides neuronal progenitor cells which have been identified in histological sections of the adult human brain. The present invention also provides methods to localize, characterize, harvest, and propagate neuronal progenitor cells derived from human brain tissue. Additional methods are provided for introducing and expressing genes in the brain. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6812027 | | Application Number: | US1999000271969 | | Date Filed: | 18/03/1999 | | Date Published: | 02/11/2004 | | Assignee: | Cornell Research Foundation, Inc., Ithaca, NY, USA |
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