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Stem Cell Related Patent Number US7132287
| Title: | Method for neural stem cell differentiation using 5HT-1A agonists | | Inventors: | Rajan, Prithi; Rockville, MD, USA | | Summary: | This invention describes a method of preparing populations of enriched mammalian neural cells via exposure of the neural stem cell population to a 5-hydroxytryptamine receptor (5HT1A) agonist. Disclosed herein are the means for differentiating a neural stem cell into a neuronal cell such as a neuroblast or a neuron, in vitro or in vivo, with an agonist such as buspirone. Amounts and frequencies of exposure to the agonist are included, such that conditions are sufficient for inducing differentiation, and for the expression of a neuronal cell marker. Therapeutic applications in the treatment of autism and stroke are also provided. | | Abstract: | The present invention relates to a method for differentiating a neural stem cell into a neuronal cell such as a neuroblast or a neuron in vitro or in vivo. Particularly, the invention provides for a method for neural stem cell differentiation by contacting the neural stem cell with a 5HT1A ligand or agonist.
The present invention relates to a method for differentiating a neural stem cell into a neuronal cell such as a neuroblast or a neuron in vitro or in vivo. Particularly, the invention provides for a method for neural stem cell differentiation by contacting the neural stem cell with a 5HT1A ligand or agonist. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US7132287 | | Application Number: | US2002000175360 | | Date Filed: | 18/06/2002 | | Date Published: | 07/11/2006 | | Assignee: | Psychiatric Genomics, Inc., Gaithersburg, MD, USA |
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